arterial blood pressure mabp  (ADInstruments)

Journal: Journal of Hypertension

Article Title: Toll-like receptor 7-driven lupus autoimmunity induces hypertension and vascular alterations in mice

doi: 10.1097/hjh.0000000000002368

Figure Lengend Snippet: FIGURE 1 Toll-like receptor 7 activation promotes blood pressure increase in imiquimod-induced autoimmunity. (a) Cumulative survival rate of BALB/c mice following topical application of IMQ on their right ears three times per week for 8 weeks. (b) Time course of SBP measured by tail-cuff plethysmography was determined in control (Ctrl) and IMQ-treated mice. (c) Mean arterial blood pressure (MABP) and (d) heart rate (HR) measured by direct recording in left carotid artery at the end of the experimental period. Experimental groups: Ctrl 4 weeks (W) (n ¼ 8), Ctrl 8W (n ¼ 8), IMQ 4W (n ¼ 8), IMQ 8W (n ¼ 8). Values are represented as mean SEM. Results were compared by one-way ANOVA and Tukey post hoc test. P less than 0.01, P less than 0.001 compared with their respective control groups.

Article Snippet: At the end of the experimental period, Health, Inc. All rights reserved. www.jhypertension.com 1323 mean arterial blood pressure (MABP) and heart rate (HR) were measured using continuous intra-arterial recording (MacLab; ADInstruments, Hastings, UK) in conscious mice under unrestrained conditions.

Techniques: Activation Assay, Control